Probiotics for AAD Prevention

Antibiotic-associated diarrhea affects up to 30% of patients receiving antibiotics. Prophylactic probiotic use is a well-established intervention.

First-Line Strains

The World Gastroenterology Organisation strongly recommends two specific probiotics for this indication:

• Saccharomyces boulardii CNCM I-745: Because it is a yeast, it can be taken simultaneously with antibiotics without degradation.
• Lactobacillus rhamnosus GG: Requires staggered administration (2 hours apart from antibiotics) but demonstrates equivalent efficacy.